Articles | Open Access | https://doi.org/10.37547/ijmsphr/Volume07Issue02-06

Intestinal Parasitic Infections In Patients With Cutaneous Leishmaniasis: Etiological Profile And Prevalence

Karimova Mavluda Turabdjanovna , Candidate of Medical Sciences, Associated professor, Department of Infectious and Children’s Infectious Diseases, Tashkent State Medical University, Tashkent, Uzbekistan
Suvonkulov Uktamjon Toirovich , PhD in Medical Sciences, Assistant, Department of Surgical Diseases, Zarmed University, Samarkand, Uzbekistan
Anvarov Jakhongir Abralovich , PhD in Medical Sciences, Associated professor, Department of Infectious and Children’s Infectious Diseases, Tashkent State Medical University, Tashkent, Uzbekistan

Abstract

This study investigated the prevalence and etiological composition of intestinal parasitic infections in patients with cutaneous leishmaniasis. The findings indicated that the prevalence of Ascaris lumbricoides infection was approximately twice as high in the study group compared to the control group. In addition, Giardia lamblia and Hymenolepis nana were detected among the patients. No significant differences were observed in the incidence of mixed parasitic infections. These results highlight the importance of timely detection of parasitic infections and the implementation of comprehensive treatment strategies in patients with cutaneous leishmaniasis.

Keywords

Cutaneous leishmaniasis, intestinal parasites, Giardia lamblia

References

World health organization. https://www.who.int/news-room/fact-sheets/detail/leishmaniasis;

Martínez, D., Llanos-Cuentas, A., Llanos-Cuentas, A., Dujardin, J.-C., Dujardin, J.-C., Polman, K., Polman, K., Adaui, V., Adaui, V., Boelaert, M., Verdonck, K., & Verdonck, K. A Case-Control Study on the Association Between Intestinal Helminth Infections and Treatment Failure in Patients With Cutaneous Leishmaniasis. Open Forum Infectious Diseases, 2020. 7(5). https://doi.org/10.1093/OFID/OFAA155;

Barbosa J.F., de Figueiredo S.M., Monteiro F. et al. New Approaches on Leishmaniasis Treatment and Prevention: A Review on Recent Patents// Recent Pat. Endocr. Metab. Immune Drug Discov. 2015 Sep 21.

Abdiev T.A., Suvonkulov U.T., Kovalenko D.A., Abdiev F.T., Arziev Kh.Yu. Prevalence of helminthiases in Uzbekistan. Problems of Biology and Medicine. – Samarkand, 2014. – No.3. – P.16–17.

Akhmedova M.D., Anvarov J.A., Suvonkulov U.T., Mirzajonova D.B., Osipova S.O. Cutaneous leishmaniasis and related tissue helminthiasis (review). Journal Infectology. 2019; 11(2):20-25. (In Russ.) https://doi.org/10.22625/2072-6732-2019-11-2-20-25

Muratov T.I., Suvonkulov U.T., Sadikov Z. Yu., Achilova O.D., Anvarov J.A., Aslonov M.N. Modern epidemiological aspects of cutaneous leishmaniasis in Uzbekistan. Bulletin of TMA. 2018. (1), 29-31. (In Russ.)

Newlove, T., Guimarães, L. H., Morgan, D. J., Alcântara, L. M., Glesby, M. J., Carvalho, E. M., & Machado, P. R. L. Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis. American Journal of Tropical Medicine and Hygiene, 2011. 84(4), 551–555. https://doi.org/10.4269/AJTMH.2011.10-0423;

Ganguli P., Chowdhury S., Chowdhury S., Sarkar R.R.Identification of Th1/Th2 regulatory switch to promote healing response during leishmaniasis: a computational approach. EURASIP J Bioinform Syst Biol. 2015 Dec 1;2015(1):13.

Saberi R., Moin-Vaziri V., Hajjaran H., Niyyati M., Taghipour N., Kheirandish F., Abadi A. Identification of Leishmania species using N-acetylglucosamine-1-phosphate transferase gene in a zoonotic cutaneous leishmaniasis focus of Iran. J Vector Borne Dis. 2018 Jan-Mar;55(1):14-19. doi: 10.4103/0972-9062.234621

Darabi S., Khaze V., Riazi-Rad F., Darabi H., Bahrami F., Ajdary S., Alimohammadian M.H. Leishmania major strains isolated from distinct endemic areas show diverse cytokine mRNA expression levels in C57BL/6 mice: Toward selecting an ideal strain for the vaccine studies. Cytokine. 2015 Dec;76(2):303-308. doi: 10.1016/j.cyto.2015.05.022. Epub 2015 Jun 10

Gabriel, Á., Valério-Bolas, A., Palma-Marques, J., Mourata-Gonçalves, P., Ruas, P., Dias-Guerreiro, T., & Santos-Gomes, G. Cutaneous Leishmaniasis: The Complexity of Host’s Effective Immune Response against a Polymorphic Parasitic Disease. Clinical & Developmental Immunology, 2019, 2603730. https://doi.org/10.1155/2019/2603730,

Amorim, C. F., Lovins, V., Singh, T. P., Novais, F. O., Lago, A. S., Carvalho, E. M., Beiting, D. P., Scott, P., & Grice, E. Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity. Science Translational Medicine, 2023. 15. https://doi.org/10.1126/scitranslmed.adh1469

Bryson K.J., Millington O.R., Mokgethi T., McGachy H.A., Brombacher F., Alexander J. BALB/c mice deficient in CD4 T cell IL-4Rα expression control Leishmania mexicana Load although female but not male mice develop a healer phenotype. PLoS Negl Trop Dis. 2011 Jan 4;5(1):e930. doi:10.1371/journal.pntd.0000930

Lazarski Ch.A., Ford J., Katzman Sh.D. et al., IL-4 attenuates Th1-associated chemokine expression and Th1 trafficking to inflamed tissues and limits pathogen clearance. PloS One. 2013; 8 (8): e71949.

Abidova Z.M., Rakhmatov A.B., Izvekova O.V., Baynazarov N.B. Immunocytokine status of patients with cutaneous leishmaniasis. Journal of Theoretical and Clinical Medicine. – Tashkent, 2014. – Vol. 2, No. 3. – P. 8.

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Karimova Mavluda Turabdjanovna, Suvonkulov Uktamjon Toirovich, & Anvarov Jakhongir Abralovich. (2026). Intestinal Parasitic Infections In Patients With Cutaneous Leishmaniasis: Etiological Profile And Prevalence. International Journal of Medical Science and Public Health Research, 7(02), 41–45. https://doi.org/10.37547/ijmsphr/Volume07Issue02-06