This article examines the results of the influence of the SPINK1 (Asn34Ser) polymorphism on the incidence of acute pancreatitis. Environmental factors, in conjunction with genetic factors, play a crucial role in the mechanism of acute pancreatitis development. It was found that there are ethnic differences in the distribution of allele and genotype frequencies of this gene's polymorphic variant. Further development of molecular genetic research through studying the genetic basis of pancreatitis is important for developing new methods of diagnosis and determining treatment strategies with an individualized approach to each patient.

Acute pancreatitis, pancreatic trypsin inhibitor (SPINK1), gene polymorphism

Arif, A.; Jaleel, F.; Rashid, K. Accuracy of BISAP score in prediction of severe acute pancreatitis. Pak. J. Med. Sci. 2019, 35, 1008-1012. [CrossRef]

Mofidi, R.; Duff, M.; Wigmore, S.; Madhavan, K.; Garden, O.; Parks, R. Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitis. Br. J. Surg. Inc. Eur. J. Surg. Swiss Surg. 2006, 93, 738-744. [CrossRef]

Shulpekova Yu. O., Kardasheva S. S., Okhlobystin A. V., Ivashkin V. T. The Role of Genetic Factors in the Development and Progression of Pancreatitis. Issues of Pediatric Dietetics. 2020; Vol. 18, No. 3. pp. 19-28.

Tarasenko S. V., Natalsky A. A., Bogomolov A. Yu., Bakonina I. V., Kadykova O. A., Andrianova K. V. Genetic polymorphisms as predisposing factors of chronic pancreatitis. Experimental and Clinical Gastroenterology. 2018; Vol. 159, No. 11. pp. 38-43.

Toth, E.; Maleth, J.; Zavogyan, N.; Fanczal, J.; Grassalkovich, A.; Erdos, R.; Pallagi, P.; Horvath, G.; Tretter, L.; Balint, E.R.; et al. Novel mitochondrial transition pore inhibitor N-methyl-4-isoleucine cyclosporin is a new therapeutic option in acute pancreatitis. J. Physiol. 2019, 597, 5879-5898. [CrossRef]

Vasudevan, S.; Goswami, P.; Sonika, U.; Thakur, B.; Sreenivas, V.; Saraya, A. Comparison of Various Scoring Systems and Biochemical Markers in Predicting the Outcome in Acute Pancreatitis. Pancreas 2018, 47, 65-71. [CrossRef] [PubMed]

Watanabe T, Yamashita K, Arai Y, et al. Chronic fibroinflammatory responses in autoimmune pancreatitis depend on IFN-α and IL-33 produced by plasmacytoid dendritic cells. J Immunol 2017;198:3886-3896.

Wu, B.U.; Johannes, R.S.; Sun, X.; Tabak, Y.; Conwell, D.L.; Banks, P.A. The early prediction of mortality in acute pancreatitis: A large population-based study. Gut 2008, 57, 1698-1703. [CrossRef] [PubMed]