Background. Atopic dermatitis is one of the most common chronic inflammatory skin diseases in children, characterized by early onset, recurrent course, and significant impact on quality of life. The heterogeneity of clinical manifestations and allergen sensitization profiles makes standard treatment approaches insufficiently effective. Recent advances in molecular allergy diagnostics, including component-resolved diagnostics, allow identification of individual allergen sensitization patterns and support personalized treatment strategies. However, the development of personalized treatment algorithms based on molecular allergy diagnostics in children with atopic dermatitis remains insufficiently studied. Aim. To develop a personalized treatment algorithm for children with atopic dermatitis based on molecular allergy diagnostics using Phadia 200 (ImmunoCAP) and MADx ALEX platforms. Materials and Methods. This prospective study will be conducted at the Republican Specialized Scientific-Practical Allergology Center between 2023 and 2026. A total of 200 children aged 3–18 years diagnosed with atopic dermatitis will be included. Clinical assessment will include dermatological examination, allergic history evaluation, and disease severity assessment using the SCORAD index. Laboratory investigations will include complete blood count, eosinophil count, and total IgE measurement. Molecular allergy diagnostics will be performed using Phadia 200 (ImmunoCAP) and MADx ALEX platforms to determine individual allergen sensitization profiles. Personalized treatment strategies will be developed based on obtained results. Statistical analysis will be performed using SPSS software, with p<0.05 considered statistically significant. Results. The study is expected to identify individual allergen sensitization profiles and their association with disease severity, frequency of exacerbations, and comorbid allergic diseases. Implementation of personalized treatment algorithms is expected to reduce disease severity, improve treatment effectiveness, and decrease recurrence frequency in children with atopic dermatitis. Conclusion. Molecular allergy diagnostics plays an important role in developing personalized treatment strategies for children with atopic dermatitis. Implementation of personalized approaches may improve diagnostic accuracy, enhance treatment effectiveness, and improve quality of life in pediatric patients.

Atopic dermatitis, children, personalized treatment

Asadova D.Sh., Karimov B.Sh. Personalized approach to the therapy of atopic dermatitis in children in the Republic of Uzbekistan // Healthcare of Uzbekistan. – 2023. – No. 2. – P. 51–58.

Karimov B.Sh., Khamraev N.U. Clinical and immunological efficacy of biological drugs in patients with severe atopic dermatitis // Bulletin of TSMU. – 2024. – No. 3. – P. 48–55.

Razikova G.R. Efficacy of a personalized treatment algorithm for patients with atopic dermatitis // Medical Journal of Uzbekistan. – 2025, No. 6, pp. 95–100.

Razikova I.S., Razikova G.R. Improving the allergology service of Uzbekistan // Allergic and Immunopathological Diseases – a Problem of the 21st Century. – 2019. – P. 23–24.

Razikova I.S. et al. Prevalence of polymorphisms RS1800925, RS20541 of the IL13 gene in atopic syndrome in the Republic of Uzbekistan // E-Conference Platform. – 2025. – Vol. 1. – No. 17-November 2025. – P. 213–213.

Razikova I.S., Aidarova N.P., Ishmuhamedova Sh.B. Dermatorespiratory syndrome and atopic march: diagnosis, clinical features // Central Asian Journal of Medical and Natural Science. – 2023. – Vol. 4. – No. 6. – P. 37–41.

Razikova I.S. et al. Assessment of the dynamics of various treatment methods for respiratory allergoses // Primary Immunodeficiencies and COVID-19. – 2023. – P. 84–91.

Akdis C.A., Agache I. Global Atlas of Allergy. — Zurich: EAACI, 2022. — 388 p.

Akdis C.A., Arkwright P.D., Bruggen M.C. Type 2 immunity in atopic dermatitis // Journal of Allergy and Clinical Immunology. — 2020. — Vol. 145(1). — P. 1–20.

Bieber T. Atopic dermatitis: an expanding therapeutic pipeline for a complex disease // Nature Reviews Drug Discovery. — 2022. — Vol. 21. — P. 21–40.

Bieber T., D'Erme A.M., Akdis C.A. Clinical phenotypes of atopic dermatitis // Allergy. — 2022. — Vol. 77(2). — P. 339–351.

Canonica G.W., Ansotegui I.J., Pawankar R. et al. AWAO digital guidelines for allergy management // World Allergy Organization Journal. — 2020. — Vol. 13(2). — P. 100091.

European Academy of Allergy and Clinical Immunology. EAACI Guidelines on Atopic Dermatitis. — 2023. — 215 p.

Hamilton R.G., Oppenheimer J. Serological IgE analyses in the diagnostic algorithm for allergic disease // Journal of Allergy and Clinical Immunology Practice. — 2018. — Vol. 6(5). — P. 1467–1476.

Langan S.M., Irvine A.D., Weidinger S. Atopic dermatitis // Lancet. — 2020. — Vol. 396. — P. 345–360.

Leung D.Y.M., Guttman-Yassky E. Deciphering the complexities of atopic dermatitis // Journal of Allergy and Clinical Immunology. — 2023. — Vol. 151(2). — P. 299–308.

Matricardi P.M., Kleine-Tebbe J., Hoffmann H.J. et al. EAACI Molecular Allergology User's Guide // Pediatric Allergy and Immunology. — 2016. — Vol. 27(Suppl. 23). — P. 1–250.

Novak N., Simon D. Atopic dermatitis – from new pathophysiologic insights to individualized therapy // Allergy. — 2021. — Vol. 76(6). — P. 1615–1628.

Paller A.S., Kabashima K., Bieber T. Therapeutic pipeline for atopic dermatitis // Journal of Allergy and Clinical Immunology. — 2021. — Vol. 148(1). — P. 72–83.

Paller A.S., Spergel J.M., Mina-Osorio P. Emerging therapies in atopic dermatitis // Journal of Allergy and Clinical Immunology. — 2020. — Vol. 145(2). — P. 421–432.

Silverberg J.I. Public health burden and epidemiology of atopic dermatitis // Dermatologic Clinics. — 2022. — Vol. 40(3). — P. 247–258.

Silverberg J.I., Thyssen J.P., Paller A.S. What's new in atopic dermatitis? // Journal of Allergy and Clinical Immunology Practice. — 2023. — Vol. 11(3). — P. 589–598.

Valenta R., Duchene M., Vrtala S. Component-resolved diagnosis in allergy // Allergy. — 2020. — Vol. 75(12). — P. 3026–3038.

Valenta R., Karaulov A., Niederberger V. et al. Molecular aspects of allergens and allergy // Advances in Immunology. — 2018. — Vol. 138. — P. 195–256.

Weidinger S., Beck L.A., Bieber T. Atopic dermatitis // Nature Reviews Disease Primers. — 2018. — Vol. 4. — P. 1–20.

Weidinger S., Novak N. Atopic dermatitis // Lancet. — 2016. — Vol. 387(10023). — P. 1109–1122.

Wollenberg A., Barbarot S., Bieber T. et al. Consensus-based European guidelines for treatment of atopic eczema // Journal of the European Academy of Dermatology and Venereology. — 2018. — Vol. 32(5). — P. 657–682.