To evaluate the effectiveness of including low-intensity laser irradiation (LILI) in the complex therapy of mild acute pancreatitis, with emphasis on pain relief, surgical strategy, and long-term treatment outcomes. Materials and Methods. A total of 60 patients with mild acute pancreatitis were examined and randomized into two groups: the main group (n=30), which received standard treatment combined with LILI, and the control group (n=30), which received standard treatment only. Treatment effectiveness was assessed based on the dynamics of pain syndrome using the visual analogue scale (VAS), the frequency of surgical interventions, length of hospital stay, and recurrence rate during 12 months of follow-up. Results. Patients in the main group demonstrated a more rapid decrease in pain intensity: the median VAS score by day 3 was 2.1 points versus 3.8 points in the control group (p<0.01). The frequency of sanitation laparoscopy was lower in the main group (10% versus 33.3%; p<0.05), as was the need for emergency cholecystectomy and ERCP. The mean length of hospital stay was reduced in the main group (3.8±0.3 versus 4.6±0.3 days; p<0.05). During one-year follow-up, recurrence of acute pancreatitis was observed in 6.7% of patients in the main group compared with 23.3% in the control group (p<0.05). The developed management algorithm allowed optimization of treatment strategy by reducing repeated hospitalizations and the number of surgical interventions. Conclusion. The inclusion of LILI in the treatment of acute pancreatitis provides faster pain relief, reduces the frequency of surgical interventions, shortens the duration of hospitalization, and decreases the risk of disease recurrence. This method may be considered a pathogenetically justified and clinically effective supplement to standard treatment protocols.

Acute pancreatitis, pain, low-intensity laser irradiation, surgical strategy

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